Daniel Koshland is a Biochemist, has a laboratory on the UCB Campus.
Koshland's Reagent is a four membered ring, 1,2 di sulfur substituted cyclo butane.
Disulfide linkages abound in biological systems. Cysteine amino acid residues cross link in an oxidative process. Koshland's reagent is a mild reagent for the reaction to oxidize two cysteine amino acid residues by taking their hydrogens. After having done so the two sulfurs are linked by a disulfide bond and the hydrogens go with the now opened ring, ring strain being relieved and the entropy change for the reaction is part of the driving force.
Eminent biochemist Daniel Koshland has died Monday July 23, 2007